Peripartum heat stress and rumen-protected methionine supplementation: effects on immune, metabolic, and inflammatory status of Holstein cows and her offspring.

基本信息

• 作者：Anne R Guadagnin; Emily Tabor; Brittney D Davidson; Maverick C Guenther; Grace Larsen; Danielle N Sherlock; Daniel Luchini; S I Arriola Apelo; Jimena Laporta
• DOI：10.3168/jds.2025-28176
• 原文链接：https://doi.org/10.3168/jds.2025-28176
• 数据来源：pubmed:pubmed-jds
• 抓取时间：2026-05-30T18:53:27+00:00
• Markdown 文件：/root/worksplace/paper-tracker/exports/obsidian/2026-05-09-peripartum-heat-stress-and-rumen-protected-methionine-supplementation-effects-on-immune,-metabolic,-and-infla.md

摘要

This study investigated how supplementing a commercially available rumen-protected methionine (RPM) to heat stressed Holstein cows during late gestation and early lactation affects immune, metabolic, and inflammatory biomarkers in the cow and their offspring exposed in utero. Fifty-three multiparous pregnant Holstein cows were housed in individual tie stalls and fed either a control dry-cow diet (CON, 2.2% Met of MP) or a CON diet supplemented with Smartamine®M (MET, 2.6% Met of MP) and were maintained under thermoneutral conditions from week -6 to -4 relative to parturition for acclimation. Four weeks before expected parturition, all MET cows and half of the CON cows were fitted with electric heat blankets (EHB) to induce HS (MET-EHB, n = 17; CON-EHB, n = 17). Cows fed CON diets without EHB served as thermoneutral controls (CON-TN, n = 19). Maternal treatments continued until 4 wk after parturition. Fifty-one calves exposed to the maternal treatments in utero for the last 4 weeks of gestation were managed identically from birth to 180 d of age. Blood samples (cows: d 1, 8, 28 postpartum; calves: d 1, 7, 21, 35, 49 of age) and liver biopsies (cows: d 8, 28 postpartum; calves: d 1, 70 of age) were collected to assess immune and metabolic responses. In cows, EHB-induced heat stress reduced liver functionality index (LFI), increased IL-6 secretion following an ex vivo LPS challenge, and decreased hepatocyte counts while accumulating GSH. Rumen-protected methionine tended to attenuate IL-6 and IL-1β responses and improved LFI and hepatic expression of Met-related genes. Heifers born to heat stressed dams were lighter and displayed decreased cytokine responses, with maternal RPM primarily improving growth. Collectively, these findings show that periparturient heat stress impairs hepatic and immune function in the cow-calf pair, and RPM may partially mitigate these effects.

中文整理

基础摘要（未启用或未成功调用大模型）：This study investigated how supplementing a commercially available rumen-protected methionine (RPM) to heat stressed Holstein cows during late gestation and early lactation affects immune, metabolic, and inflammatory biomarkers in the cow and their offspring exposed in utero. Fifty-three multiparous pregnant Holstein cows were housed in individual tie stalls and fed either a control dry-cow diet (CON, 2.2% Met of MP) or a CON diet supplemented with Smartamine®M (MET, 2.6% Met of MP) and were maintained under thermoneutral conditions from week -6 to -4 relative to parturition for acclimation. Four weeks before expected parturition, all MET cows and half of the CON cows were fitted with electr

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相关性说明

命中 奶牛/牛只 关键词：cow, heifer, calf；命中 农业电气化与自动化 关键词：electric