Pleiotropic effects of the milk somatic cell transcriptome associated with feed efficiency and immunity in Holstein dairy cows.

基本信息

• 作者：V Asselstine; F S Schenkel; F Miglior; C F Baes; P Stothard; A Cánovas
• DOI：10.3168/jds.2025-27824
• 原文链接：https://doi.org/10.3168/jds.2025-27824
• 数据来源：pubmed:pubmed-jds
• 抓取时间：2026-05-30T18:53:27+00:00
• Markdown 文件：/root/worksplace/paper-tracker/exports/obsidian/2026-05-09-pleiotropic-effects-of-the-milk-somatic-cell-transcriptome-associated-with-feed-efficiency-and-immunity-in-ho.md

摘要

In the livestock industry, feed is the largest expense, driving interest in breeding more feed-efficient animals. Residual feed intake (RFI) is a widely used measure of feed efficiency, accounting for actual feed intake versus expected requirements for maintenance and production. Because feed efficiency is highly polygenic, associated genes may have pleiotropic effects on traits such as immunity, complicating breeding strategies. One way to study pleiotropy is through -OMICs technologies, including transcriptomics, which uses RNA-Sequencing (RNA-Seq) to analyze the transcriptome at specific tissue levels and time points. This study used RNA-Seq to identify differentially expressed (DE) genes between Low RFI (n = 22) and High RFI (n = 17) Holstein cows. A total of 36 genes were DE between groups, enriched in 28 significant metabolic pathways, most of which were immune-related, including the RIG-I-like receptor signaling pathway. QTL annotation and enrichment analyses were also performed for the DEG. Within these gene regions, 646 previously annotated QTL were identified, of which 26.7% were related to milk traits. Notably, 10 QTL were associated with feed efficiency, while 4 were linked to host immunity. QTL enrichment further revealed 387 significantly enriched QTL, with the majority of the top associations related to health. In summary, this research identified candidate genes and QTL regions suggesting potential pleiotropic relationships between feed efficiency and immunity in Holstein dairy cows. These findings highlight the need for further investigation to balance productivity and health in genetic improvement programs.

中文整理

基础摘要（未启用或未成功调用大模型）：In the livestock industry, feed is the largest expense, driving interest in breeding more feed-efficient animals. Residual feed intake (RFI) is a widely used measure of feed efficiency, accounting for actual feed intake versus expected requirements for maintenance and production. Because feed efficiency is highly polygenic, associated genes may have pleiotropic effects on traits such as immunity, complicating breeding strategies. One way to study pleiotropy is through -OMICs technologies, including transcriptomics, which uses RNA-Sequencing (RNA-Seq) to analyze the transcriptome at specific tissue levels and time points. This study used RNA-Seq to identify differentially expressed (DE) genes

关键词标签

相关性说明

命中 奶牛/牛只 关键词：dairy cow, cow；命中 农业智能装备 关键词：iot